Table 5 Histopathology of rats on day 28 of subacute feeding test of Py-mulin
From: Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate
Organ | Histopathological characters | 28-day (n = 10) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Control | 50 mg/kg b.w. | 100 mg/kg b.w. | 300 mg/kg b.w. | ||||||
Female | Male | Female | Male | Female | Male | Female | Male | ||
Liver | Inflammatory cells | 1/5 | 1/5 | 2/5 | 0/5 | 2/5 | 1/5 | 1/5 | 1/5 |
Congestion | 1/5 | 0/5 | 0/5 | 0/5 | 1/5 | 1/5 | 1/5 | 2/5 | |
Edema | 0/5 | 0/5 | 0/5 | 1/5 | 1/5 | 0/5 | 2/5 | 1/5 | |
Heart | Erythrocytosis | 1/5 | 0/5 | 2/5 | 0/5 | 2/5 | 1/5 | 0/5 | 1/5 |
Edema | 0/5 | 0/5 | 1/5 | 0/5 | 3/5 | 0/5 | 1/5 | 0/5 | |
Spleen | Erythrocytosis | 0/5 | 1/5 | 0/5 | 1/5 | 1/5 | 1/5 | 1/5 | 1/5 |
Congestion | 0/5 | 0/5 | 1/5 | 0/5 | 1/5 | 1/5 | 0/5 | 1/5 | |
Lungs | Connective tissues proliferation | 1/5 | 1/5 | 1/5 | 2/5 | 1/5 | 0/5 | 2/5 | 2/5 |
Congestion | 0/5 | 1/5 | 1/5 | 0/5 | 0/5 | 0/5 | 0/5 | 2/5 | |
Ovaries | Congestion | 0/5 | ˗˗ | 2/5 | ˗˗ | 1/5 | ˗˗ | 1/5 | ˗˗ |