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Table 5 Histopathology of rats on day 28 of subacute feeding test of Py-mulin

From: Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate

Organ Histopathological characters 28-day (n = 10)
Control 50 mg/kg b.w. 100 mg/kg b.w. 300 mg/kg b.w.
Female Male Female Male Female Male Female Male
Liver Inflammatory cells 1/5 1/5 2/5 0/5 2/5 1/5 1/5 1/5
Congestion 1/5 0/5 0/5 0/5 1/5 1/5 1/5 2/5
Edema 0/5 0/5 0/5 1/5 1/5 0/5 2/5 1/5
Heart Erythrocytosis 1/5 0/5 2/5 0/5 2/5 1/5 0/5 1/5
Edema 0/5 0/5 1/5 0/5 3/5 0/5 1/5 0/5
Spleen Erythrocytosis 0/5 1/5 0/5 1/5 1/5 1/5 1/5 1/5
Congestion 0/5 0/5 1/5 0/5 1/5 1/5 0/5 1/5
Lungs Connective tissues proliferation 1/5 1/5 1/5 2/5 1/5 0/5 2/5 2/5
Congestion 0/5 1/5 1/5 0/5 0/5 0/5 0/5 2/5
Ovaries Congestion 0/5 ˗˗ 2/5 ˗˗ 1/5 ˗˗ 1/5 ˗˗