Table 6 Ames test results of Py-mulin using S. typhimurium strains TA97, TA98, TA100, TA102 and TA1535
From: Acute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate
Substance | Dose (μg/plate) | TA97 | TA98 | TA100 | TA1535 | ||||
|---|---|---|---|---|---|---|---|---|---|
- S9 | + S9 | - S9 | + S9 | - S9 | + S9 | - S9 | + S9 | ||
Py-mulin | 1000 | 46.3 ± 3.5** | 55.0 ± 4.6** | 21.0 ± 2.6 | 19.7 ± 3.5 | 36.7 ± 3.1** | 38.0 ± 3.6** | 20.7 ± 3.1 | 27.3 ± 2.5 |
200 | 62.0 ± 5.3 | 62.7 ± 4.2** | 22.7 ± 3.1 | 26.7 ± 2.5 | 83.7 ± 4.5* | 73.3 ± 3.1** | 25.0 ± 2.6 | 38.7 ± 3.5 | |
40 | 72.0 ± 3.6 | 77.7 ± 3.2 | 33.3 ± 4.5 | 28.0 ± 4.9 | 93.7 ± 4.2 | 89.0 ± 8.5 | 34.3 ± 4.0 | 41.7 ± 4.7 | |
8 | 80.3 ± 4.7 | 79.3 ± 5.1 | 23.7 ± 4.0 | 24.7 ± 5.5 | 105.7 ± 6.7 | 101.3 ± 3.5 | 38.7 ± 4.7 | 36.7 ± 5.0 | |
1.6 | 76.3 ± 5.6 | 94.3 ± 4.0 | 32.7 ± 3.5 | 31.7 ± 3.1 | 112.0 ± 5.3 | 115.0 ± 5.0 | 42.0 ± 4.4 | 44.3 ± 5.5 | |
Vehicle control | 84.0 ± 5.0 | 98.3 ± 5.1 | 24.7 ± 3.5 | 29.7 ± 2.1 | 111.3 ± 4.2 | 120.0 ± 5.6 | 34.7 ± 4.2 | 43.3 ± 5.7 | |
Positive control | 737.3 ± 13.3** | 964.7 ± 13.0** | 567.7 ± 11.5** | 614.0 ± 15.1** | 913.3 ± 20.8** | 1212.3 ± 12.9** | 583.0 ± 13.7** | 746.3 ± 12.6** | |