Skip to main content
Fig. 10 | BMC Pharmacology and Toxicology

Fig. 10

From: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Fig. 10

An electron micrograph of the cross sections of the kidney in (A) group Ӏ and (B) group ӀӀ showing the glomerular filtration barrier (arrows) form of epithelial and endothelial laminae densa. The glomerular blood capillaries contain red blood cells (arrow head. The renal glomeruli reveal podocytes (P) having a nucleus (N) and primary (curved arrow) and secondary (F) foot processes. (C) group ӀӀӀ showing discontinuity of the glomerular filtration barrier (arrow. The podocyte (P) have dense nucleus (N), many vacuolations (V) and primary foot processes (curved arrow. Disrupted dense fused secondary foot processes (F) can be noticed. The glomerular blood capillaries contain red blood cells (arrow. (D) group Ӏ and (E) group ӀӀ showing a part of the proximal convoluted tubule (PT. The tubular lining cells have apical microvilli (mv), euchromatic nuclei (N), numerous mitochondria (m) and pinocytotic vesicles (pv. (F) group ӀӀӀ showing the tubular lining cells have apical microvilli (mv), electron dense nuclei (N),few electron dense itochondria (m),and pinocytotic vesicles (pv. Vacuolated cytoplasm (V) is noticed. (G) group Ӏ showing a part of the distal convoluted tubule (DT. The lining cells have euchromatic nuclei (N), few mitochondria (m) and pinocytotic vesicles (pv. Note few short apical microvilli (mv. (H) group ӀӀ showing the tubular cells with destructed mitochondria (m) and vacuolated cytoplasm (V. Disrupted apical microvilli (mv) and distorted shape of the nucleus (N) are observed. (I) group ӀӀӀ showing the cytoplasm of the tubular cells reveals vacuolations (v), and dense mitochondria (m. Distorted electron dense nucleus (N) and pyknotic one (arrow head) are seen. Exudates inside tubular lumen (curved arrow) and destructed apical microvilli (mv) are noticed. (A-C: TEM × 10,000, D-F: TEM × 7200, G-I:TEM × 4800, Scale bar = 2 μm)

Back to article page