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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Fig. 3

An electron micrograph of the longitudinal sections of the cardiac tissues in (A) group Ӏ showing regular arranged cardiac myofibres (F) with a regular pattern of the sarcomeres and striations (arrow),numerous intact mitochondria (M), intercalated disc (arrow head) and the cardiomyocytes nuclei (N. (B) group ӀӀ showing normal histological structure of most cardiac myofibres (F. Degenerated area of some cardiac myofibres (curved arrow) are seen. (C&D) group ӀӀӀ showing thinning of many myofibres with obscured striations (arrow. Other myofibres reveals destructed area (curved arrow. Many vacuolation (V), extravasation of the red blood cells (arrow head),dense cardiomyocytes nuclei (N) and swollen destructed mitochondria (M) are observed. (TEM × 4800, Scale bar = 2 μm)

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