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Fig. 6 | BMC Pharmacology and Toxicology

Fig. 6

From: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Fig. 6

An electron micrograph of the cross sections of the hepatic tissues in (A) group Ӏ and (B) group ӀӀ showing the hepatocyte with ill defined borders, euchromatic nucleus (N) and prominent nucleolus (n. The cytoplasm shows many mitochondria (M), free ribosomes (R) and few lysosomes (L. Intact linings of the hepatic sinusoids (S), Ito cells (I) and von Kupffer cell (K) are noticed. (C-E) group ӀӀӀ showing shrunken dense nuclei (N) with indentation of the nuclear membrane (curved arrow. Marked loss of the cell organelles, electron dense shrunken cytoplasm (asterisk), swollen destructed mitochondria (M), vacuolations (arrow) and extravasation of the red blood cells (open arrow) are observed. (TEM × 4800, Scale bar = 2 μm)

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