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Fig. 8 | BMC Pharmacology and Toxicology

Fig. 8

From: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Fig. 8

A photomicrograph of the cross sections of the kidney in (A) group Ӏ and (B) group ӀӀ showing normal epithelial lining cells (arrow heads) of the proximal (PT) and distal (DT) convoluted tubules. The glomerulus (G) displays flattened cells (arrow) of the parietal layer of the Bowman’s capsule, the cells of the visceral layer (open arrow) and the Bowman’s space (asterisk. (C) group ӀӀӀ showing many vacuolations (curved arrows) in the proximal (PT) and distal (DT) convoluted tubular cells. The tubular epithelial cells showed deeply stained pyknotic nuclei and vacuolated cytoplasm. Some tubular cells reveal deeply stained pyknotic nuclei (arrow head. Dilated Bowman’s space (asterisk), cellular debris inside tubule (double arrow) are seen. (D) group Ӏ and (E) group ӀӀ showing normal histological architechure of the glomerulus (G), proximal (PT) with brush border (arrow) and distal (DT) convoluted tubules. (F) group ӀӀӀ showing loss of normal architecture of tubular cells of the proximal (PT) and distal (DT) convoluted tubules. The glomerulus (G) reveals many vacuolations (arrows. (A-C: H&E × 1000, d-f: Toluidine blue × 1000, Scale bar = 10 μm)

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