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Fig. 9 | BMC Pharmacology and Toxicology

Fig. 9

From: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Fig. 9

A photomicrograph of the cross sections of the kidney in (A) group Ӏ showing strong PAS reaction in the glomerular mesangium (arrow head), the basement membraneʼs renal tubules (arrow) and in the apical microvilli (curved arrow) of the proximal convoluted tubules (B) group ӀӀ appears more or less similar to group Ӏ (C) group ӀӀӀ showing weak PAS reaction in the glomerular mesangium (arrow head), the basement membraneʼs renal tubules (arrow) and in the brush borders (curved arrow) of the proximal convoluted tubules (D) group Ӏ showing normal amount of collagen fibers around the renal tubules (arrow) and Bowman’s capsules (arrow head) (E) group ӀӀ showing apparently mild increase in the collagen fibers distribution around the renal tubules (arrow) and Bowman’s capsules (arrow head) (F) group ӀӀӀ showing apparently moderate increase in the collagen fibers distribution around the renal tubules (arrow) and Bowman’s capsules (arrow head. (A-C: PAS × 400, D-F: Masson’s trichrome × 400, Scale bar = 20 μm)

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