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Table 2 Area percent (%) of collagen deposition and area percent (%) of Caspase 3 expression in the examined tissues among the experimental groups

From: RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Groups

Group I

Group II

Group III

P- Value

Parameters

Area %collagen (Heart)

2.97 ± 0.6

5.28 ± 1.1 a,c

27.6 ± 1.9 a,b

<  0.0001*

Area %collagen (Liver)

7.48 ± 0.8

17.53 ± 1.1 a,c

26.94 ± 0.9 a,b

<  0.0001*

Area % collagen (Kidney)

3.81 ± 0.7

8.35 ± 0.7 a,c

29.72 ± 2.4a, b

<  0.0001*

Area % caspase (Heart)

2.47 ± 0.5

9.56 ± 0.9 a,c

20.56 ± 2.7 a,b

<  0.0001*

Area % caspase (Liver)

4.34 ± 0.9

12.65 ± 1.2 a,c

18.27 ± 1.9 a,b

<  0.0001*

Area % caspase (Kidney)

5.42 ± 1.5

12.04 ± 1.2 a,c

24.60 ± 1.3a, b

<  0.0001*

  1. Data are represented as Mean ± SD. * means statistically significant difference
  2. a statistically significanEt when compared to the group I, P <  0.05
  3. b statistically significant when compared to the group II, P <  0.05
  4. c statistically significant when compared to the group III, P < 0.05