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Table 1 Demographic and clinical characteristics of the patients with serum APAP concentration above or under 100-treatment line

From: Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines

   Under 100-line (n = 126) Above 100-line (n = 46) p-value
Gender, Male 29 (16.9) 22 (17.5) 7 (15.2) 0.728
Age (year) 23 (17–38) 24 (17–37) 22 (18–38) 0.683
Intentionality 160 (93.0) 116 (92.1) 44 (95.7) 0.414
Weight (kg) 57.0 (50.0–63.0) 57.0 (50.0–63.0) 56.5 (46.0–60.0) 0.220
Total ingested dose (g) 7.7 (5.0–12.0) 6.0 (4.9–10.0) 10.0 (6.0–16.5) < 0.001
Ingested dose per kilogram of weight (mg/kg) 133.3 (88.5–199.3) 106.5 (80.0–153.1) 248.1 (158.3–391.3) < 0.001
Time from ingestion to presentation (minute) 172 (77–332) 139 (67–309) 241 (145–468) 0.002
Time from ingestion to administration of activated charcoal (minute)a 152 (85–271) 117 (76–221) 207 (123–364) 0.003
Acute starvation 9 (5.2) 6 (4.8) 3 (6.5) 0.646
Chronic liver disease 1 (0.6) 0 (0.0) 1 (2.2) 0.097
Chronic alcohol consumption 14 (8.1) 10 (7.9) 4 (8.7) 0.872
Co-ingestionb 33 (19.2) 26 (20.6) 7 (15.2) 0.424
Activated charcoala 120 (69.8) 90 (71.4) 30 (65.2) 0.432
N-acetylcysteine treatment 131 (76.2) 86 (68.3) 45 (97.8) < 0.001
Albumin (g/dL) 4.6 (4.4–4.8) 4.6 (4.4–4.8) 4.5 (4.3–4.8) 0.464
Acute liver injury 9 (5.2) 7 (5.6) 2 (4.3) 0.753
  1. Table 1. Variables are expressed as n (%) or median (interquartile range).
  2. a n = 120
  3. b Co-ingestion: overdose with substances that delayed gastric emptying or induced hepatic enzymes