Table 1 Demographic and clinical characteristics of the patients with serum APAP concentration above or under 100-treatment line
From: Evaluation of cut-off values in acute paracetamol overdose following the United Kingdom guidelines
Under 100-line (n = 126) | Above 100-line (n = 46) | p-value | ||
|---|---|---|---|---|
Gender, Male | 29 (16.9) | 22 (17.5) | 7 (15.2) | 0.728 |
Age (year) | 23 (17–38) | 24 (17–37) | 22 (18–38) | 0.683 |
Intentionality | 160 (93.0) | 116 (92.1) | 44 (95.7) | 0.414 |
Weight (kg) | 57.0 (50.0–63.0) | 57.0 (50.0–63.0) | 56.5 (46.0–60.0) | 0.220 |
Total ingested dose (g) | 7.7 (5.0–12.0) | 6.0 (4.9–10.0) | 10.0 (6.0–16.5) | < 0.001 |
Ingested dose per kilogram of weight (mg/kg) | 133.3 (88.5–199.3) | 106.5 (80.0–153.1) | 248.1 (158.3–391.3) | < 0.001 |
Time from ingestion to presentation (minute) | 172 (77–332) | 139 (67–309) | 241 (145–468) | 0.002 |
Time from ingestion to administration of activated charcoal (minute)a | 152 (85–271) | 117 (76–221) | 207 (123–364) | 0.003 |
Acute starvation | 9 (5.2) | 6 (4.8) | 3 (6.5) | 0.646 |
Chronic liver disease | 1 (0.6) | 0 (0.0) | 1 (2.2) | 0.097 |
Chronic alcohol consumption | 14 (8.1) | 10 (7.9) | 4 (8.7) | 0.872 |
Co-ingestionb | 33 (19.2) | 26 (20.6) | 7 (15.2) | 0.424 |
Activated charcoala | 120 (69.8) | 90 (71.4) | 30 (65.2) | 0.432 |
N-acetylcysteine treatment | 131 (76.2) | 86 (68.3) | 45 (97.8) | < 0.001 |
Albumin (g/dL) | 4.6 (4.4–4.8) | 4.6 (4.4–4.8) | 4.5 (4.3–4.8) | 0.464 |
Acute liver injury | 9 (5.2) | 7 (5.6) | 2 (4.3) | 0.753 |