Table 2 Parameters used to describe cases in the dataset
From: Open-access database of literature derived drug-related Torsade de Pointes cases
Parameter Group | Parameter Name |
|---|---|
Case ID | unique case identified |
Source | author, year, PMID |
Patient/population characteristic | age, sex, diseases |
Patient’s general health parameters | blood pressure, heart rate, breaths (respiratory rate), temperature |
Drugs and alcohol intake | main suspected drug (name, dose, route of administration, additional dosing information, therapeutic range), concomitant drugs (name, dose, route of administration, additional dosing information), overdose (y/n), alcohol |
Lab measurements | blood pH, creatinine kinase, blood urea nitrogen, the plasma concentration of: main suspected drug, sodium, potassium, magnesium, calcium, chloride, bicarbonate, lactic acid |
ECG parameters | QRS, QT, QTc interval duration |
Clinical management and outcome | Applied clinical TdP management, post-intervention QRS, QT/QTc, outcome |
Comments | Additional comments |
Drug’s properties | SMILES, molecular weight, total polar surface area, logP, H-bond acceptors, H-bond donors, number of rotatable bonds, number of heavy atoms |
FDA reports related to the suspected drug | Total number of reports, number of cardiac cases, number of TdP cases, deaths due to TdP |