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Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data

Fig. 1

Goodness-of-fit scatter plots for the final population pharmacokinetic model. A. Observed concentrations (DV) vs. predicted concentrations (PRED); the solid line represents the reference line. B. Observed concentrations (DV) vs. individual predicted concentrations (IPRED); the solid line represents the reference line. C. Conditional weighted residuals (CWRES) vs. predicted concentrations (PRED); the solid and dotted horizontal lines represent the reference line and ± 2 standard deviations, respectively. The red curve is a loess curve fit to the absolute values of the residuals. The bottom red curve is the reflection of the top red curve about the x-axis. The blue line is the loess curve fit to the raw residuals. D. Conditional weighted residuals (CWRES) vs. time after the first dose (TIME); the solid and dotted lines represent the reference line and ± 2 standard deviations, respectively. The red curve is a loess curve fit to the absolute values of the residuals. The bottom red curve is the reflection of the top red curve about the x-axis. The blue line is the loess curve fit to the raw residuals

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