Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data

Table 3 Final population pharmacokinetic model estimates and bootstrap results

Parameter	Estimated mean	RSE %	Bootstrap mean	95% CI
Population value
CL/F, L/h	6.209	2.830	6.215	6.207–6.223
CL_CR on CL/F	0.409	9.491	0.415	0.412–0.417
Amiodarone on CL/F	−0.238	3.158	−0.243	−0.246 – − 0.241
Vd/F, L/kg (fixed)	6.000	NA	6.000	NA
k_a, h⁻¹ (fixed)	1.000	NA	1.000	NA
Interindividual variability
ωCL/F, %	34.4	2.9	34.2	34.1–34.4
Intraindividual variability
Multiplicative, %	36.6	3.2	36.5	34.3–38.9

CI confidence interval, CL_CR creatinine clearance, CL/F oral clearance, k_a absorption rate constant, NA not available, RSE relative standard error, Vd/F apparent volume distribution
The final model parameters were as follows
CL/F = 6.2 × (CLcr/60)^0.41 × (1 − 0.24 × [if amiodarone])
Vd/F = 6.0 × Body weight
k_a = 1.0

ISSN: 2050-6511