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Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway

Fig. 5

DEX protects HT22 cells against propofol-induced apoptosis by regulating Arc expression. A HT22 cell apoptosis detected using Hochest 33,258 staining; B HT22 cell apoptosis rate following exposure to the study drug or shArc; C HT22 cell viability and proliferation determined through CCK-8 assay; the mRNA expression levels of miR-377-5p (D), DNMT3A (E), and caspase-3 (F) quantified using RT-qPCR. Each value represents the mean ± SD for n = 3. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. DEX, dexmedetomidine; KD, knockdown

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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