Table 1 Top 10 upregulated or downregulated DEGs in HQ-induced K562 cells

LILRA6

leukocyte immunoglobulin like receptor A6

0.4

6.4

4.17

0.025*

KISS1

KiSS-1 metastasis-suppressor

0.4

6.2

4.15

0.031*

GPR35

G protein-coupled receptor 35

0.7

10.1

3.84

0.006**

CREB3L3

cAMP responsive element binding protein 3 like 3

0.7

8.5

3.58

0.012*

THBS1

thrombospondin 1

31.8

317.2

3.32

0.000***

PI16

peptidase inhibitor 16

6.7

44.9

2.74

0.000***

CCL2

C-C motif chemokine ligand 2

11.7

56.3

2.27

0.000***

IGFBP5

insulin like growth factor binding protein 5

18.4

80.3

2.13

0.031*

CHGB

chromogranin B

2.8

11.9

2.07

0.037*

ITGA3

integrin subunit alpha 3

11.3

44.7

1.98

0.000***

KIF19

kinesin family member 19

10.6

1.8

−2.57

0.018*

BMP2

bone morphogenetic protein 2

9.9

1.6

−2.66

0.018*

LRRTM1

leucine rich repeat transmembrane neuronal 1

8.9

1.3

−2.79

0.023*

NMUR1

neuromedin U receptor 1

21.9

2.9

−2.94

0.000***

MARVELD3

MARVEL domain containing 3

7.4

1.0

−2.94

0.037*

ACTL10

actin like 10

12.7

1.5

−3.04

0.002***

LRRC14B

leucine rich repeat containing 14B

6.4

0.6

−3.41

0.046*

KRT36

keratin 36

7.1

0.6

−3.47

0.024*

GOLGA8Q

golgin subfamily A

5.7

0.3

−4.25

0.045*

HBB

hemoglobin subunit beta

370.6

12.0

−4.95

0.029*