Identification of potential pathways and microRNA-mRNA networks associated with benzene metabolite hydroquinone-induced hematotoxicity in human leukemia K562 cells

Table 2 Top 10 upregulated or downregulated DEMs in HQ-induced K562 cells

miRNA name	C	HQ	Log₂ (HQ/C)	P-value
miR-1246	1278	28,646	4.49	0.001***
miR-224	251	909	1.86	0.034*
miR-572	51	150	1.55	0.033*
miR-129-3p	63	166	1.41	0.026*
miR-29a	86	219	1.35	0.011*
miR-27a	128	291	1.18	0.039*
miR-452	22	49	1.16	0.045*
miR-376a	24	40	0.77	0.030*
miR-3191	25	41	0.75	0.025*
miR-4763-3p	70	90	0.36	0.009**
miR-4778-5p	4845	1973	−1.3	0.008**
miR-4298	4588	1859	−1.3	0.011*
miR-23b*	28	12	−1.3	0.015*
miR-4732-3p	34	14	−1.32	0.007**
miR-7	158	58	−1.46	0.032*
miR-135b	28	10	−1.48	0.043*
miR-18a	1917	661	−1.54	0.002***
miR-92a-1*	118	38	−1.65	0.030*
miR-25*	209	66	−1.66	0.002***
miR-4423-3p	81	14	−2.58	0.028*

* represents P value < 0.05; ** represents P value < 0.01; *** represents P value < 0.005

ISSN: 2050-6511