Identification of potential pathways and microRNA-mRNA networks associated with benzene metabolite hydroquinone-induced hematotoxicity in human leukemia K562 cells

Table 4 KEGG analysis of leukemia related pathways

KEGG term	ID	Input number	Background number	Regulated	Genes
Chronic myeloid leukemia	hsa05220	4	73	up	CRK, CHUK, NFKB1, NRAS
Chronic myeloid leukemia	hsa05220	6	73	down	STAT5B, MAP 2 K2, PIK3CD, GAB2, SHC2, MAPK3
Acute myeloid leukemia	hsa05221	4	57	up	KIT, CHUK, NFKB1, NRAS
Acute myeloid leukemia	hsa05221	8	57	down	PPARD, MAP2K2, SPI1, PIM1, PIK3CD, STAT5B, MAPK3, STAT3
Hematopoietic cell lineage	hsa04640	4	88	up	KIT, CD44, THPO, ITGA3
Hematopoietic cell lineage	hsa04640	9	88	down	ITGAM, ITGA2B, CD19, ANPEP, CD33, CD7, IL9R, CD37, ITGA5
Human T-cell leukemia virus 1 infection	hsa05166	17	261	up	PCNA, ANAPC10, CDC23, NFKB1, POLE3, FOSL1, ATR, VAC14, CDC26, CHUK, ETS2, POLE4, RANBP1, VDAC3, MRAS, CREM, NRAS
Human T-cell leukemia virus 1 infection	hsa05166	22	261	down	STAT5B, HLA-E, TP53INP1, HLA-A, NFATC2, TNFRSF13C, FZD4, FZD2, IL15RA, PIK3CD, TLN1, NFATC4, HLA-B, WNT11, ATF3, SPI1, RRAS, MAP3K3, WNT6, HLA-C, TSPO, SLC25A6

ISSN: 2050-6511