Fig. 3

Lentinan antagonized oxidative stress and inflammatory signals in liver. A. Histogram of oxidative stress indicators MDA, GSH after SA treatment or Lentinan intervention. An increased MDA and a reduced GSH in liver were found in SA treatment group, which were antagonized consistently by Lentinan intervention; B Characteristics of inflammatory signals OX40, IL-17A after SA treatment or Lentinan intervention. SA induced the upregulations of proinflammatory signals OX40, IL-17A, while was downregulated significantly after Lentinan intervention. Data were expressed as mean ± SD; n = 5. The levels of MDA, GSH, OX40, and IL-17A in liver tissues were quantified by the convertion of OD values to nanomole or picogram values of per gram liver tissue (nmol or pg/g tissue) according to the standard curve and dilution ratio. Significant difference was obtained by independent sample’s t-test followed ANOVA. ^*P < 0.05 indicates a significant difference compared with control; ^#P < 0.05 indicates a significant difference compared with SA treatment. Abbreviations: IL, Interleukin; MDA, malondialdehyde; GSH, glutathione; OX40 (CD134), Tumor necrosis factor receptor superfamily member 4