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Table 2 Overview of common gene expression level changes in PHMG-p long-term treated HPAEpiCs and their reported expression changes in lung cancer

From: Analysis of lung cancer-related genetic changes in long-term and low-dose polyhexamethylene guanidine phosphate (PHMG-p) treated human pulmonary alveolar epithelial cells

Gene symbol

Entrez ID

Description

Biotype

Fold change (FC)*

Expression

Reference(s)

#14/#13

#16/#15

#18/#17

SNORA26

677810

small nucleolar RNA, H/ACA box 26

snoRNA

75.6

39.7

38.6

-

-

IFI6

2537

interferon alpha inducible protein 6

protein coding

2.23

3.81

7.01

-

-

MX1

4599

MX dynamin like GTPase 1

protein coding

2.25

4.14

4.41

Up

[25]

MMP1

4312

matrix metallopeptidase 1

protein coding

4.79

4.79

3.76

Up

[26,27,28]

ISG15

9636

ISG15 ubiquitin-like modifier

protein coding

2.19

4.72

3.36

Up

[29]

Dn

[30]

HMGA2

8091

high mobility group AT-hook 2

protein coding

2.27

2.95

3.20

Up

[31,32,33,34]

PLAT

5327

plasminogen activator, tissue type

protein coding

2.87

3.25

3.20

Up

[35, 36]

KRT19

3880

keratin 19

protein coding

2.04

2.64

2.97

Up

[37,38,39]

IL33

90865

interleukin 33

protein coding

2.30

2.01

2.68

Up

[40,41,42]

TRPA1

8989

transient receptor potential cation channel subfamily A member 1

protein coding

2.48

2.33

2.50

Up

[43, 44]

AK5

26289

adenylate kinase 5

protein coding

2.27

2.35

2.35

Dn

[45]

NT5E

4907

5'-nucleotidase ecto

protein coding

2.17

2.22

2.30

Up

[46,47,48]

PLAU

5328

plasminogen activator, urokinase (uPA)

protein coding

2.23

2.93

2.06

Up

[49,50,51]

MIR3687-2

103504728

microRNA 3687–2

miRNA

2.22

10,900

2.01

Up

[52, 53]

CDKN1A

1026

cyclin-dependent kinase inhibitor 1A

protein coding

3.36

2.38

2.00

Up

[54]

Dn

[55]

TBX4

9496

T-box 4

protein coding

0.409

0.384

0.448

Dn

[56,57,58]

SLITRK6

84189

SLIT and NTRK like family member 6

protein coding

0.451

0.277

0.476

-

-

TIMP3

7078

TIMP metallopeptidase inhibitor 3

protein coding

0.463

0.454

0.470

Dn

[59, 60]

H19

283120

H19, imprinted maternally expressed transcript

lncRNA

0.293

0.279

0.497

Up

[61,62,63]

COL14A1

7373

collagen type XIV alpha 1

protein coding

0.432

0.334

0.448

Dn

[64]

FMO3

2328

flavin containing monooxygenase 3

protein coding

0.486

0.279

0.432

-

-

FMO2

2327

flavin containing monooxygenase 2

protein coding

0.457

0.295

0.415

Dn

[65, 66]

GPX3

2878

glutathione peroxidase 3

protein coding

0.486

0.409

0.387

Dn

[67, 68]

NDUFA4L2

56901

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2

protein coding

0.351

0.174

0.486

Up

[69]

HBG1

3047

hemoglobin subunit gamma 1

protein coding

0.291

0.454

0.358

Dn

[70, 71]

MGP

4256

matrix Gla protein

protein coding

0.395

0.328

0.299

Dn

[72]

LOC103021295

103021295

uncharacterized LOC103021295

lncRNA

0.448

0.186

0.257

-

-

HBG2

3048

hemoglobin subunit gamma 2

protein coding

0.160

0.158

0.245

Dn

[71]

MIR490

574443

microRNA 490

miRNA

0.0412

0.0163

0.0237

Dn

[73,74,75,76]

  1. (Dn: Down), (*: The FC value is provided as whole number, and the number of significant figures is specified as three.)