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Fig. 4 | BMC Pharmacology and Toxicology

Fig. 4

From: Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β

Fig. 4

CoCl2 in A549 cells reduced the FRET fluorescence signal of pAcGFP1-AhR and pDsRed-Monomer-ARNT. A pAcGFP1-N1-AhR and pDsRed-Monomer-ARNT recombinant plasmids were transfected into A549 cells; 24 h later, the cells were treated with 8 μM BaP for 24 h. B pAcGFP1-AhR and pDsRed-Monomer-ARNT recombinant plasmids were transfected into A549 cells; 24 h later, the cells were treated for 24 h with 8 μM BaP under hypoxic conditions. In A549 cells, BaP enhanced the pAcGFP1-AhR and pDsRed-Monomer-ARNT FRET fluorescent signal in dose-dependent manner,* P < 0.05, ** P < 0.01, n = 3

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