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Table 2 Changes in the serum markers at baseline and postintervention

From: Aspirin versus placebo on estrogen levels in postmenopausal women: a double-blind randomized controlled clinical trial

Serum Levels of Markers

Aspirin group

Placebo group

Aspirin vs. placebo

Baseline

At the end of the intervention period

p-value*

Baseline

At the end of the intervention period

p-value*

At the end of the intervention period

Aspirin

At the end of the intervention period

Placebo

p-value**

Estradiol (pg/mL) Median (IQR)

15.00 (12.00–20.90)

12.70 (8.50–16.60)

0.01*

15.00 (11.35–22.25)

16.50 (11.30–22.10)

0.12

12.70 (8.50–16.60)

16.50 (11.30–22.10)

<  0.01

Testosterone (ng/dL) Median (IQR)

0.50 (0.40–0.80)

0.50 (0.40–0.70)

0.51

0.40 (0.40–0.60)

0.40 (0.40–0.60)

0.10

0.50 (0.40–0.70)

0.40 (0.40–0.60)

0.58

SHBG (nmol/L) Median (IQR)

26.30 (17.50–36.00)

26.00 (19.70–33.70)

0.80

26.30 (14.32–33.50)

25.20 (13.42–28.27)

0.08

26.00 (19.70–33.70)

25.20 (13.42–28.27)

0.33

  1. SHBG Sex Hormone Binding Globulin
  2. * Wilcoxon signed-rank test
  3. ** Mann–Whitney U test