Fig. 1
A Model of surface metastasis in PM and its potential further enhancement by taurolidine despite its antitumoral effects on in-vivo colon cancer cells. 1) Model of peritoneal metastatic nodule and 2) mobilization of cells and cell-clusters by destabilization of the cancer nodule by taurolidine. B Light-microscopy of in-vitro colon cancer (HT-29) cell cultures (Magnification 40X). 24 h after treatment structural changes are visible in the taurolidine group. 1). Untreated cells with their typical features (Yellow arrows: 1. compact/tight interaction 2. Polyhexagonal wall formation 3. Polystructural shape with interaction to the bottom 4. Cells are within a narrow visual band and therefore better visible 1) and 2.) Cells treated with taurolidine (green arrows: 1. floating round shape polycell clusters and 2. single detached shere shape cells with little contact to the bottom and the surrounding cells)