Molecule | Target | APTT2x | PT2x |
---|
EA | FXIIIa | >  > 2200 µM | >  > 2200 µM |
Dabigatran | FIIa | 0.32 µM | 0.33 µM |
Rivaroxaban | FXa | 0.19 µM | 0.15 µM |
AntiF11 | FXIa | 2.2 µg/mL | >  > 3.5 µg/mL |
- APTT2x: The concentration required to double the clotting times of normal human plasma under APTT conditions. PT2x: The concentration required to double the clotting time of normal human plasma under PT conditions. Experiment with EA was repeated at least three times, however for the other molecules, experiments were repeated two times because results were highly reproducible with little variability and were consistent with reported values