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Table 2 Antiviral activity of two-drug combinations treatment against SARS-CoV-2 in Vero E6 cells

From: Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations

Drug treatment

IC50 (μM) qRT-PCR

Fold reduction of IC50 (single/combined)

Niclosamide-ivermectin

 Niclosamide

0.043

 

  Niclosamide + ivermectin 2.4 μM

ND

ND

  Niclosamide + ivermectin 1.2 μM

ND

ND

  Niclosamide + ivermectin 0.6 μM

0.018

2.399

  Niclosamide + ivermectin 0.3 μM

0.022

1.955

 Ivermectin

1.27

 

  Ivermectin + niclosamide 0.09 μM

ND

ND

  Ivermectin + niclosamide 0.0045 μM

ND

ND

  Ivermectin + niclosamide 0.0225 μM

0.313

4.06

  Ivermectin + niclosamide 0.01125 μM

0.660

1.92

Niclosamide-chloroquine

 Niclosamide

0.043

 

  Niclosamide + chloroquine 1.7 μM

ND

ND

  Niclosamide + chloroquine 0.85 μM

ND

ND

  Niclosamide + chloroquine 0.425 μM

0.013

3.308

  Niclosamide + chloroquine 0.2125 μM

0.029

1.483

 Chloroquine

0.89

 

  Chloroquine + niclosamide 0.09 μM

ND

ND

  Chloroquine + niclosamide 0.0045 μM

ND

ND

  Chloroquine + niclosamide 0.0225 μM

0.249

3.57

  Chloroquine + niclosamide 0.01125 μM

0.531

1.68

Ivermectin-chloroquine

 Ivermectin

1.27

 

  Ivermectin + chloroquine 1.7 μM

ND

ND

  Ivermectin + chloroquine 0.85 μM

ND

ND

  Ivermectin + chloroquine 0.425 μM

0.515

2.47

  Ivermectin + chloroquine 0.2125 μM

0.821

1.55

 Chloroquine

0.89

 

  Chloroquine + ivermectin 2.4 μM

ND

ND

  Chloroquine + ivermectin 1.2 μM

ND

ND

  Chloroquine + ivermectin 0.6 μM

0.315

2.83

  Chloroquine + ivermectin 0.3 μM

0.514

1.73

  1. ND not determined, cannot calculate IC50 with the least curve fit of the data sets