Fig. 2
Chemical structures of the best compounds and toxicology summary [29, 31,32,33] compared to reference anti-CA drug PF-74. Detailed synthesis and characterization of 696 and 314 are available in supporting information. EC50 (concentration of a drug that gives half-maximal response) corresponds to the cytotoxicity of the compounds. LD50 correspond to the oral acute toxicity in rat or mice, and AMES test predicts mutagenicity