Table 2 The ten most frequently occurring potential drug-drug interactions in the cardiovascular intensive care unit

aspirin/clopidogrel

Major

22

Increased risk of bleeding

aspirin/nitroglycerin

Moderate

21

Increased nitroglycerin concentrations and additive platelet function depression

aspirin/insulin

Moderate

19

Increased risk of hypoglycemia

methylprednisolone/insulin

Moderate

17

Increased risk of bleeding or diminished effects of warfarin

aspirin/metoprolol

Moderate

15

Increased blood pressure

digoxin/torsemide

Moderate

13

Increased risk of digoxin toxicity (nausea, vomiting, cardiac arrhythmias)

candesartan/potassium chloride

Moderate

13

Increased risk of hyperkalemia

metoprolol/lidocaine

Major

12

Increased risk of lidocaine toxicity (anxiety, myocardial depression, cardiac arrest)

morphine/ticagrelor

Major

11

Increased morphine exposure

moxifloxacin/amiodarone

Major

10

Increased risk of QTc prolonging effects