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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model

Fig. 2

DIZE improved cardiac contractility and reduced plasma BNP and TNI levels. Comparison of LVSP (a), +dp/dtmax (b), and -dp/dtmax (c), as well as plasma concentrations of TnI (d) and BNP (e) in the sham, CLP, and CLP + DIZE treatment groups (n = 6 rats/group). * P < 0.05 vs sham group, ** P < 0.01 vs sham group; # P < 0.05 vs CLP group, ## P < 0.01 vs CLP group. Abbreviations: CLP, cecal ligation and puncture; DIZE, diminazene aceturate; LVSP, left ventricular systolic pressure; +dp/dtmax, maximal left ventricular pressure rising rate; −dp/dtmax, maximal left ventricular pressure declining rate; TnI, troponin I; BNP, brain natriuretic peptide

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