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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Intratesticular versus intraperitoneal injection of Busulfan for the induction of azoospermia in a rat model

Fig. 3

H & E staining of hepatic sections after Busulfan injection: (a, d) No adverse effects were seen on hepatic tissue after injection of 5 mg/kg Busulfan via IT compared to the control rats. (b, c) Following IP injections of Busulfan, numerous focal hemorrhagic, mild cholangitis, hyperemia, swelling, and hepatocytes degeneration and infiltrated inflammatory cells around portal tracts were seen in the liver tissue sections. Our findings showed notable hepatic toxicity in rats that received 40 mg/kg IP Busulfan which was quite severe than 10 mg/kg rats. Images scale bar; 50 μm. Abbreviations: CV, central vein; PV, portal vein; BD, bile duct; HA, hepatic artery; thin arrows, infiltrated inflammatory cells; thick arrows, swelled and degenerated hepatocytes; Star, mild cholangitis, (n = 8)

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