Skip to main content
Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions

Fig. 1

Systemic anaphylactic or anaphylactoid reactions evoked by macromolecules of TW80 (n = 6). A, Anaphylactic test in guinea pigs: Guinea pigs received 3 doses (10%, 0.5 ml) of intraperitoneal injection for sensitization and a dose (15 mg/ml, 0.5 ml) of intravenous injection for evocation; B, Anaphylactoid test in guinea pigs: Guinea pigs received a dose (15 mg, 1 ml) of intravenous injection for evocation without sensitization; C, Anaphylactoid test in rabbits: rabbits received a dose (70 mg, 0.7 ml) of intravenous injection for evocation without sensitization. The symptom with the high score appeared in 30 min after the last administration was recorded according to Table 1. A high score means a severe reaction. Com A, Component A (above 100 kDa); Com B, Component B (from 10 to 100 kDa); Com C, Component C (below 10 kDa); Ori, the original TW80; and NS, normal saline for injection. *, P < 0.05 vs NS; #, P < 0.05 vs Ori; Mann Whitney test

Back to article page