Fig. 4
From: Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions
Serum factors in anaphylactoid rabbits (mean + SD, n = 6). Rabbits received a dose (70 mg, 0.7 ml) of intravenous injection for evocation without sensitization, and the serum was obtained 30 min following the evocation. Serum factors, including soluble complement terminal complex Sc5b-9 (Sc5b-9), complement factor B (CFb), mannose binding lectin (MBL), bradykinin (BK), β-hexosaminidase (β-HEX), lysozyme (LZM), and histamine (HIS), were detected using ELISA kits. Com A, Component A (above 100 kDa); Com B, Component B (from 10 to 100 kDa); Com C, Component C (below 10 kDa); Ori, the original TW80; and NS, normal saline for injection. *, P < 0.05 vs NS; #, P < 0.05 vs Ori; ANOVA