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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Resveratrol’s neural protective effects for the injured embryoid body and cerebral organoid

Fig. 3

The neural proliferation in embryoid bodies and cerebral organoids after resveratrol (RSV) treatment. A-B, the ki67 (red) positive cells in each group, at D5, the cell number is decreased in the D-gal group compared to that in the control group, and RSV can rescue the cell’s decline, and the cells’ amount at D12 has the same trend as that at D5 (p < 0.05), DAPI (blue) was used as counterstaining. C, the expression of Sox2 (green) is similar to results as ki67 positive cells in various groups. D-F, β-III-tublin (green) and ki67 (red) immunolabeling. RSV can rescue the cells’ decrease. E-F, at D5 and D12, β-III-tublin-positive cells decrease in the D-gal group compared to that in the control group (p < 0.05), the amounts of β-III-tublin in the RSV-L increases significantly (p < 0.05), compared with that in D-gal group. G, H, statistical analyses show the ki67 and β-III-tublin-positive cells increased significantly in the RSV-L and RSV-M at D5, D8 and D12. A-C & E-F, scale bars = 20 μm; D, scale bars = 50 μm

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