Development of a particle swarm optimization-backpropagation artificial neural network model and effects of age and gender on pharmacokinetics study of omeprazole enteric-coated tablets in Chinese population

Table 2 The pharmacokinetics parameters of all subjects, the low-age and high-age groups and male and female groups

Pharmacokinetics Parameters	All subjects	Male group	Female group	Low-age group	High-age group
AUC0-t(ng∙h∙mL-1)	980 ± 1121	1067 ± 1232	715 ± 1000	1262 ± 1410	496 ± 486
AUC0-∞(ng∙h∙mL-1)	1063 ± 1264	1144 ± 1384	782 ± 1138	1393 ± 1598	506 ± 499
Cmax(ng∙mL-1)	379 ± 297	425 ± 341	283 ± 234	435 ± 330	266 ± 234
Tmax(h)	4.50(1.00,8.00)	4.00(1.00,5.50)	4.50(1.50,8.00)	4.50(1.50,8.00)	4.50(1.00,6.00)
t1/2(h)	1.25 ± 0.64	1.27 ± 0.71	1.14 ± 0.59	1.44 ± 0.81	0.97 ± 0.27

AUC0-t: Area under the concentration–time curve from dose to last measurable concentration
AUC0-∞: Area under the concentration–time curve from dose to infinity
Cmax Peak concentration, Tmax Time from dose to Cmax, t1/2 Half-life of terminal elimination
Data are shown as Mean ± SD except for Tmax which are shown as median (range)

ISSN: 2050-6511