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Table 3 The effect of pharmacokinetic parameters of Age and Gender in healthy Chinese subjects

From: Development of a particle swarm optimization-backpropagation artificial neural network model and effects of age and gender on pharmacokinetics study of omeprazole enteric-coated tablets in Chinese population

Pharmacokinetics Parameters P

Age

Gender

Cmax(ng∙mL-1)

 < .05(.049)

.103

Tmax(h)

.921

.210

AUC0-t(ng∙h∙mL-1)

 < .05(.017)

.287

AUC0-∞(ng∙h∙mL-1)

 < .05(.014)

.233

t1/2(h)

 < .05(.011)

.514

  1. AUC0-t: Area under the concentration–time curve from dose to last measurable concentration
  2. AUC0-∞: Area under the concentration–time curve from dose to infinity
  3. Cmax Peak concentration, Tmax Time from dose to Cmax, t1/2 Half-life of terminal elimination
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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