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Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: Fluvastatin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells by inducing bone morphogenetic protein 2

Fig. 1

Effects of fluvastatin during chondrogenic differentiation of hADMSCs. A Effects of fluvastatin on cell viability of hADMSCs. hADMSCs were treated with fluvastatin at 0, 0.01, 0.1 or 1 μM for 2 weeks. Cell viability is shown relative to the level on treatment with 0 μM fluvastatin. Error bars denote the means ± standard deviation (n = 5). **p < 0.01, NS: not significant by Tukey–Kramer test. B Relative SOX9 mRNA levels on day 4 during chondrogenic differentiation of hADMSCs assessed by qRT-PCR; control, fluvastatin, and TGFβ1 groups are shown. Gene expression is given relative to the level in the control group. Error bars denote means ± standard deviation (n = 4). *p < 0.05, **p < 0.01 by Tukey–Kramer test. C Effects of fluvastatin on gene expression during chondrogenic differentiation of hADMSCs, as determined by qRT-PCR. Relative mRNA levels of SOX9, ACAN, COL2A1, and COL10A1 in chondrogenic differentiation of hADMSCs on days 0, 7, and 14 among control, fluvastatin, and TGFβ1 groups. Gene expression at each stage is shown relative to the level on day 0. Error bars denote the means ± standard deviation (n = 5). *p < 0.05, **p < 0.01 by Tukey–Kramer test

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