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Table 4 Top 10 drugs for cutaneous adverse drug reactions

From: Pharmacovigilance of cutaneous adverse drug reactions in associations with drugs and medical conditions: a retrospective study of hospitalized patients

Medication

ACDR Cases

Composition ratio (%)a

Total medication suppliedb

Total ADR Cases (Non-CASE)

Frequencyc

ORd

ROR (95%CI)

Antibiotics

  Cefoperazone sodium and sulbactam sodium injection

45

5.24

7117

71

6.3

1.457

1.45 (95% CI: 1.08–1.84)*

  Ceftriaxone sodium injection

30

3.50

1445

42

20.8

1.643

1.64 (95% CI: 0.68–2.61)

  Levofloxacin mesylate and sodium chloride injection

27

3.14

1585

46

17.0

1.350

1.35 (95% CI: 0.87–1.83)

  Levofloxacin mesylate injection

26

3.03

1549

49

16.8

1.220

1.22 (95% CI: 0.74–1.70)

  Piperacillin sodium and tazobactam sodium injection

21

2.45

4507

32

4.7

1.509

1.50 (95% CI: 0.95–2.07)

  Potassium sodium dehydroandrographolide succinate injection

21

2.45

7309

23

2.9

2.10

2.10 (95% CI: 1.50–2.70)*

  Ciprofloxacin lactate injection

17

1.98

563

30

30.2

1.303

1.30 (95% CI: 0.70–1.90)

  Levofloxacin lactate and sodium chloride injection

15

1.75

1751

36

8.6

0.95

0.95 (95% CI: 0.35–1.57)

  Herbal medicine

       

  Safflower injection

15

1.75

799

15

18.8

1.380

1.38 (95% CI: 0.73–2.02)

  Sanqi Panax notoginseng injectionLevofloxacin lactate and sodium chloride injection

23

2.68

5822

35

4.0

1.511

1.51 (95% CI: 0.98–2.04)

  Total

240

27.97

     
  1. a% of total CADR cases (858); btotal medication prescribed and supplied by the hospital; cACDR case number per 1000 users; dodds ratio of the case verses the non-case obtained by Case-non-case analysis; *Reporting adds ratio (ROR), the lower bound of the 95% CI greater than 1 showing a statistical significance