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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm

Fig. 2

DEX alleviates the H2O2-induced reduction in cell viability. A Chemical structure of DEX. B The viability of VSMCs treated with different concentrations (0, 0.1, 1, 10 μM) of DEX was detected by CCK-8. C Viability changes of VSMCs after treatment with different concentrations (0.2, 0.5, 1, 10 mM/ml) of H2O2. D Viability of VSMCs after treatment with 1 mM/ml H2O2 and different concentrations of DEX (0, 0.1, 1, 10 μM). E Viability of VSMCs in the control group, the H2O2 group, H2O2 + NS group and the H2O2 + DEX group. *p < 0.05, **p < 0.01, ***p < 0.001. DEX, dexmedetomidine

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