Fig. 3

DEX attenuates the promoting effects of H₂O₂ on cell malignancy. A Immunofluorescence of intracellular ROS in the control group, the DEX group, the H₂O₂ group, H₂O₂ + NS group, the H₂O₂ + DEX group, the H₂O₂ + DEX + BRL group, and the H₂O₂ + SB group. B Wound healing assays of cell migration in indicated groups. C Transwell assays of cell invasion in different groups. *p < 0.05, **p < 0.01. DEX, dexmedetomidine; BRL, BRL44408, α2AR inhibitor; SB, SB216763, GSK-3β inhibitor. D Quantification of ROS production. E Quantification of the percentage of remaining area. F Quantification of the number of invaded cells