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Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm

Fig. 5

DEX regulates the GSK-3β/MKP-1/Nrf2 pathway. A RT-qPCR of α2AR level in IA and STA. (N = 80). B IHC of α2AR level in IA and STA. C-G The protein levels of α2AR, p-GSK-3β/ GSK-3β, MKP-1, and NRF2 were measured by western blotting. **p < 0.01, ***p < 0.001. DEX, dexmedetomidine; BRL, BRL44408, α2AR inhibitor; SB, SB216763, GSK-3β inhibitor

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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