Y-BOCS subscale score reduction | Treatment group | ||||||
---|---|---|---|---|---|---|---|
granisetron + sertraline | placebo + sertraline | ||||||
Mean ± SD | MD (95% CI) | p-Value | Mean ± SD | MD (95% CI) | p-Value | ||
Obsession | Week 4 | 12.7 ± 4.36 | 3.92 (1.86–5.97) | 0.0003 | 13 ± 4.11 | 1.75 (-0.71-4.21) | 0.15 |
Week 8 | 10.41 ± 4.4 | 6.21 (4.14–8.27) | 0.0001 | 11.45 ± 3.66 | 3.3 (0.97–5.62) | 0.006 | |
Week 10 | 9 ± 4.87 | 7.62 (5.40–9.83) | 0.0001 | 10.05 ± 3.6 | 4.7 (2.39-7.00) | 0.0002 | |
Compulsion | Week 4 | 10.8 ± 5.15 | 1.68 (-1.20-4.56) | 0.24 | 11.55 ± 3.8 | 0.95 (-1.24-3.14) | 0.38 |
Week 8 | 4.93 ± 4.86 | 3.16 (0.35–5.96) | 0.02 | 9.45 ± 3.84 | 3.05 (0.84–5.25) | 0.007 | |
Week 10 | 8.84 ± 5.21 | 3.64 (0.73–6.54) | 0.01 | 9.05 ± 3.91 | 3.45 (1.22–5.67) | 0.003 | |
Total | Week 4 | 23.32 ± 8.83 | 5.6(1.21–9.98) | 0.013 | 24.6 ± 6.42 | 2.9 (-6.47- 0.67) | 0.10 |
Week 8 | 19.6 ± 8.55 | 9.32 (5.01–13.62) | 0.0001 | 20.9 ± 6.19 | 6.6 (3.09–10.10) | 0.0005 | |
Week 10 | 17.72 ± 9.34 | 11.2 (6.65–15.74) | 0.0001 | 19.1 ± 6.51 | 8.4 (4.78–12.01) | 0.001 |