Skip to main content

Table 2 Comparison of Yale-Brown obsessive-compulsive scale (Y-BOCS) subscales score change from baseline for treatment groups

From: Granisetron-mediated augmentation of sertraline therapeutic effect in obsessive-compulsive disorder: a double-blind placebo-controlled, randomized clinical trial

Y-BOCS subscale score reduction

Treatment group

granisetron + sertraline

placebo + sertraline

Mean ± SD

MD (95% CI)

p-Value

Mean ± SD

MD (95% CI)

p-Value

Obsession

Week 4

12.7 ± 4.36

3.92

(1.86–5.97)

0.0003

13 ± 4.11

1.75

(-0.71-4.21)

0.15

Week 8

10.41 ± 4.4

6.21 (4.14–8.27)

0.0001

11.45 ± 3.66

3.3 (0.97–5.62)

0.006

Week 10

9 ± 4.87

7.62

(5.40–9.83)

0.0001

10.05 ± 3.6

4.7

(2.39-7.00)

0.0002

Compulsion

Week 4

10.8 ± 5.15

1.68

(-1.20-4.56)

0.24

11.55 ± 3.8

0.95

(-1.24-3.14)

0.38

Week 8

4.93 ± 4.86

3.16 (0.35–5.96)

0.02

9.45 ± 3.84

3.05 (0.84–5.25)

0.007

Week 10

8.84 ± 5.21

3.64

(0.73–6.54)

0.01

9.05 ± 3.91

3.45

(1.22–5.67)

0.003

Total

Week 4

23.32 ± 8.83

5.6(1.21–9.98)

0.013

24.6 ± 6.42

2.9 (-6.47- 0.67)

0.10

Week 8

19.6 ± 8.55

9.32 (5.01–13.62)

0.0001

20.9 ± 6.19

6.6 (3.09–10.10)

0.0005

Week 10

17.72 ± 9.34

11.2 (6.65–15.74)

0.0001

19.1 ± 6.51

8.4 (4.78–12.01)

0.001

  1. SD: standard deviation; Y-BOCS: Yale-Brown Obsessive-Compulsive Scale; CI: confidence interval; MD: mean difference;