Fig. 4

Evaluation of the effect of resveratrol on the liver injury after I/R by histopathological analysis. In mice in the IR and IR + DMSO groups (A, B), obvious sinusoidal congestion, vacuolation of the hepatocytes, and focal parenchyma inflammation were obvious. Mice with mild sinusoidal dilation received resveratrol at 0.02 and 0.2 mg/kg. Abnormal histopathological changes in the resveratrol group (C, D) were significantly improved. A higher dose (2 mg/kg) of resveratrol did not have a significant protective effect on the treatment of I/R injury in mice (E). Low doses of resveratrol significantly decreased the focal inflammation compared to 2 mg/kg of resveratrol (F). The score of histopathological changes (G) of sinusoidal congestion, vacuolation of hepatocytes, focal inflammation, and the number of Kupffer cells. *P <0.05, I/R+DMSO versus I/R+Res 0.02 and I/R+Res 0.2. ^†P <0.05 I/R+Res 2.0 versus I/R+Res 0.02 and I/R+Res 0.2