The effectiveness of pregabalin with or without agomelatine in the treatment of chronic low back pain: a double-blind, placebo-controlled, randomized clinical trial

Table 4 Comparison of the improvement of outcome measures between the two study groups

Outcome of interest	Pregabalin ± Placebo (n = 23)	Pregabalin ± agomelatine (n = 23)	t	P-Value
BPI	1.74 ± 0.96	2.49 ± 1.05	0.502	0.61
RMDQ	4.13 ± 1.87	4.83 ± 1.89	0.781	0.44
SF-36	11.61 ± 4.28	15.83 ± 4.96	0.282	0.28
HADS	2.48 ± 4.2	4.78 ± 5.4	0.495	0.49
GHQ-28	3.7 ± 1.22	13.1 ± 4.71	3.173	0.003

BPI: Brief Pain Inventory; RMDQ: Roland-Morris Disability Questionnaire; SF-36: 36-Item Short Form Survey; HADS: Hospital Anxiety and Depression Scale; GHQ-28: General Health Questionnaire – 28
Data are presented with mean ± SD and analyzed by paired t-test. A P < 0.05 is considered significant

ISSN: 2050-6511