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Fig. 4 | BMC Pharmacology and Toxicology

Fig. 4

From: β-Hydroxyphosphocarnitine modifies fibrosis, steatosis and improves liver function in non-alcoholic steatohepatitis induced in rats

Fig. 4

Effect of β-HPC on α-SMA expression and localization in rats with NASH. The localization of α-SMA in liver slices was determined using immunofluorescence. Positive cells show green in color. A Control group. B β-HPC group: isolated α-SMA cells are seen throughout the parenchyma. C Non-treated NASH group: localization of α-SMA in liver tissue. Immunoreactive cells were observed in the bridges of collagen, indicating activated HSC. D NASH group treated with 100 mg/Kg -1–1: reduced amount of immunoreactive cells, α-SMA cells were distributed throughout the parenchyma and no presence of bridges was detected. Magnification of 40X

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