β-Hydroxyphosphocarnitine modifies fibrosis, steatosis and improves liver function in non-alcoholic steatohepatitis induced in rats

Table 1 Effect of β-HPC on histopathological changes of the liver

*Groups*	*Necrosis*								*Ballooned hepatocytes*
	Score (# of animals)								Score (# of animals)
	0	1		2	3		4		0		1			2
Control	5	0		0	0		0		5		0			0
β-HPC	5	0		0	0		0		5		0			0
NASH	0	0		1	4		0		0		0			5
NASH + β-HPC	0	0		2	3		0		5		0			0
Groups	Portal inflammation score (# of animals)								Focal inflammation score (# of animals)
Groups	0	1		2	3		4		0	1	2		3	4
Control	5	0		0	0		0		5	0	0		0	0
β-HPC	5	0		0	0		0		5	0	0		0	0
NASH	0	5		0	0		0		0	0	0		5	0
NASH + β-HFC	0	5		0	0		0		0	0	2		3	0
	Grading and stages of fibrosis (# of animals)
	0		1			2		3		4		5		6
Control	5		0			0		0		0		0		0
β-HPC	5		0			0		0		0		0		0
NASH	0		0			5		0		0		0		0
NASH + β-HPC	0		5			0		0		0		0		0

Values represents the number of animals per group, classified by degree of damage. The analysis was based on the Metavir and Ishak criteria

ISSN: 2050-6511