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Fig. 7 | BMC Pharmacology and Toxicology

Fig. 7

From: Novel lipid-coated mesoporous silica nanoparticles loaded with thymoquinone formulation to increase its bioavailability in the brain and organs of Wistar rats

Fig. 7

Hematoxylin and eosin-stained histological kidney sections (H & E x400). a) Control untreated rats showing a standard histological structure of the renal tubular epithelium, interstitial tissue, and glomeruli. b) TQ-treated rats showing vacuolization of the renal tubular epithelium that involves a few convoluted tubules in the renal cortex associated with few mononuclear cell infiltrations in the renal interstitial tissue. c) MSN-treated rats showing tubular epithelium vacuolization and necrosis with few mononuclear cell infiltration. d) MSN-treated rats showing cellular and hyaline aggregation in the tubular lumina. e) LB-MSN-treated rats showing necrobiotic and inflammatory reactions in the renal tissue. f) LB-MSN-treated rats showing renal tubular epithelium necrosis with hyaline droplet formation in the tubular epithelium

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