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Table 1 TQ distribution (μg/g tissue) in the different areas of the brain, liver, and kidney in the experimental groups

From: Novel lipid-coated mesoporous silica nanoparticles loaded with thymoquinone formulation to increase its bioavailability in the brain and organs of Wistar rats

Areas

TQ

LB-MSNs

Significance

%D

Mean ± SEM

Mean ± SEM

Cerebellum

0.048 ± 0.018

0.012 ± 0.0003

ns

−74.13%

Cortex

0.025 ± 0.004

0.014 ± 0.003

*

−44%

Hippocampus

0.002 ± 0.0003

0.013 ± 0.0019

ns

399.25%

Hypothalamus

0.01 ± 0.0003

0.034 ± 0.0151

ns

251.60%

Medulla

0.006 ± 0.001

0.011 ± 0.002

ns

76.37%

Midbrain

0.007 ± 0.001

0.011 ± 0.02

ns

57.14%

Striatum

0.013 ± 0.001

0.007 ± 0.001

ns

−94.90%

Thalamus

0.004 ± 0.001

0.007 ± 0.001

*

81.74%

Liver

0.201 ± 0.024

0.114 ± 0.007

ns

−43.35%

Kidney

0.112 ± 0.019

0.071 ± 0.015

ns

−36.72%

  1. %D: percentage difference in comparison to the TQ group.
  2. TQ Free thymoquinone (60 mg/kg), LB-MSNs Lipid bilayer-coated MSNs (60 mg of TQ/kg to 60 mg of MSNs/kg)
  3. *Significant; ns: nonsignificant
  4. *One-way ANOVA test was used as statistical analysis.