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Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: Overexpression of estrogen receptor β inhibits cellular functions of human hepatic stellate cells and promotes the anti-fibrosis effect of calycosin via inhibiting STAT3 phosphorylation

Fig. 5

The effects of ERβ overexpression and calycosin on JAK2/STAT3 pathway in TGF-β1-induced LX-2 cells. A Representative blots of p-JAK2, JAK2, p-STAT3, STAT3 proteins detected by western blot. B, C Relative quantification analysis of p-JAK2, JAK2, p-STAT3, STAT3 protein expressions and the ratios of p-JAK2/ JAK2 and p-STAT3/STAT3. GAPDH was used as an internal control. Data are shown as mean ± SD of three independent experiments. ##p < 0.05 vs vehicle group; **p < 0.01, ***p < 0.001 vs TGF-β1 group; +p < 0.05, ++p < 0.01 vs the corresponding treatment groups without ERβ overexpression

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