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Fig. 9 | BMC Pharmacology and Toxicology

Fig. 9

From: Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway

Fig. 9

Effect of cornin on autophagy in OGD/R-induced U87 cells through the PI3K/Akt/mTOR signaling pathway. A LY294002 (10 μM), a PI3K inhibitor, was used as pretreatment for 6 h, and then incubated with cornin (100 nM) for 48 h. Western blotting of the associated proteins and density analysis were performed, and the full-length blots/gels are presented in Figure S5. The results are presented as the mean ± SD, (n = 3). **P < 0.01 vs. the control group; #P < 0.05, ##P < 0.01 vs. the OGD/R group; ΔP < 0.05, ΔΔP < 0.01 vs. 100 nM cornin group. B U87 cells were pretreated using mTOR siRNA for 6 h followed by western blotting using western blot analysis, and the full-length blots/gels are presented in Figure S6. The results are presented as the mean ± SD, (n = 3). *P < 0.05, **P < 0.01 vs. siRNA-free treatment group; and #P < 0.05, ##P < 0.01 vs. the control group, respectively; ΔP < 0.05, ΔΔP < 0.01 vs. OGD/R group

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