Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway

Table 1 Effect of cornin on survival rate, infaract volume, and neurological scores post CI/R

Group	Survival rate	Infarct volume (%)	Neurological scores
Sham	20/20	0 ± 0	1.8 ± 0.57
MCAO	15/20	30.6 ± 4.5^##	15.1 ± 2.8^##
Cornin (2.5 mg/kg)	17/20	28.3 ± 3.0	12.7 ± 3.8
Cornin (5 mg/kg)	17/20	25.6 ± 5.3	11.0 ± 2.8^*
Cornin (10 mg/kg)	18/20	20.8 ± 4.5^**	10.4 ± 2.8^**

Data are presented as the mean ± SD. Comparison of neurological deficit scores among groups using Kruskal Wallis followed by Dunn’s test.
^*P < 0.05
^**P < 0.01 vs. MCAO group
^##P < 0.01 vs. Sham group

ISSN: 2050-6511