Table 1 Effects of SAA on Hematology of dogs

WBC (10⁹/L)

End of dose phase

End of recovery phase

14.11 ± 2.48

12.93 ± 5.30

11.59 ± 1.89

12.24 ± 1.22

10.99 ± 2.02

10.57 ± 3.15

14.19 ± 8.29

10.73 ± 0.89

NEU % (%)

End of dose phase

End of recovery phase

76.72 ± 10.06

67.24 ± 7.54

74.30 ± 7.58

68.23 ± 5.64

72.70 ± 6.13

72.59 ± 3.49

81.88 ± 4.37

84.60 ± 6.01

LYM% (%)

End of dose phase

End of recovery phase

12.34 ± 5.99

16.55 ± 5.02

15.01 ± 4.70

19.23 ± 8.34

15.74 ± 4.57

15.26 ± 2.35

10.82 ± 3.64

7.57 ± 1.28

MONO% (%)

End of dose phase

End of recovery phase

7.24 ± 3.20

10.86 ± 5.65

7.11 ± 1.97

8.28 ± 0.83

7.65 ± 2.92

8.10 ± 0.82

5.31 ± 1.88

6.53 ± 4.57

EOS% (%)

End of dose phase

End of recovery phase

3.31 ± 1.40

5.07 ± 2.91

3.01 ± 1.86

3.86 ± 3.74

3.57 ± 1.22

3.57 ± 0.29

1.78 ± 0.98

1.09 ± 0.18

BASO% (%)

End of dose phase

End of recovery phase

0.38 ± 0.35

0.29 ± 0.21

0.57 ± 0.40

0.43 ± 0.21

0.35 ± 0.51

0.48 ± 0.04

0.20 ± 0.11

0.21 ± 0.01

RBC (10¹²/L)

End of dose phase

End of recovery phase

6.73 ± 0.40

6.38 ± 0.15

7.09 ± 0.52

6.73 ± 0.43

6.35 ± 0.38

6.74 ± 0.53

6.11 ± 0.90

5.15 ± 0.36

HGB (g/dL)

End of dose phase

End of recovery phase

15.22 ± 1.44

14.15 ± 1.20

15.95 ± 1.36

15.60 ± 0.28

14.38 ± 0.50

15.60 ± 1.27

12.84 ± 1.80*

11.45 ± 1.63

HCT (fL)

End of dose phase

End of recovery phase

46.62 ± 3.89

42.70 ± 4.53

49.02 ± 3.37

46.80 ± 1.56

44.45 ± 1.59

46.90 ± 2.83

39.26 ± 5.49**

35.25 ± 5.44

MCV (fL)

End of dose phase

End of recovery phase

69.25 ± 3.48

66.95 ± 5.59

69.18 ± 1.77

69.70 ± 2.12

70.22 ± 3.58

69.70 ± 1.27

64.50 ± 5.35

68.30 ± 5.80

MCH (pg)

End of dose phase

End of recovery phase

22.60 ± 1.33

22.15 ± 1.34

22.50 ± 0.78

23.25 ± 1.06

22.75 ± 1.34

23.15 ± 0.07

21.10 ± 1.43

22.20 ± 1.56

MCHC (g/dL)

End of dose phase

End of recovery phase

32.63 ± 0.77

33.20 ± 0.71

32.53 ± 1.05

33.35 ± 0.49

32.37 ± 0.61

33.20 ± 0.71

32.76 ± 1.01

32.50 ± 0.42

PLT (10⁹/L)

End of dose phase

End of recovery phase

378.17 ± 59.50

273.00 ± 43.84

319.17 ± 43.21

337.50 ± 89.80

307.67 ± 61.31

288.50 ± 4.95

312.40 ± 128.53

456.00 ± 117.38

RET% (%)

End of dose phase

End of recovery phase

11.73 ± 7.34

15.10 ± 8.77

8.63 ± 0.48

7.90 ± 0.28

8.93 ± 0.70

8.40 ± 0.42

8.70 ± 0.71

8.50 ± 0.28

PT (sec)

End of dose phase

End of recovery phase

1.48 ± 0.12

1.50 ± 0.14

1.38 ± 0.23

1.60 ± 0.14

1.47 ± 0.27

1.60 ± 0.28

1.48 ± 0.33

1.55 ± 0.35

*P < 0.05, **P < 0.01 vs. Control. Abbreviations: WBC, White blood cell count; NEU, Neutrophil; LYM, Lymphocyte; MONO, Monocyte; EOS, Eosinophils; BASO, Basophil; RBC, Red blood cell; HGB, Hemoglobin; HCT, Hematocrit; MCV, Mean corpuscular volume; MCH, Mean corpuscular hemoglobin; MCHC, Mean corpuscular hemoglobin concentration; PLT, Platelet; RET, Reticulocyte; PT, Thrombin time.