Parameter Detection time | Control | SAA 20 mg/kg | SAA 80 mg/kg | SAA 300 mg/kg |
---|---|---|---|---|
AST (U/L) End of dose phase End of recovery phase | 40.33 ± 6.06 47.00 ± 1.41 | 44.50 ± 7.40 36.50 ± 6.36 | 40.50 ± 8.22 39.50 ± 4.95 | 49.40 ± 21.31 39.50 ± 3.54 |
ALT (U/L) End of dose phase End of recovery phase | 29.17 ± 6.43 27.00 ± 1.41 | 32.67 ± 5.72 21.00 ± 2.83 | 47.17 ± 15.96 23.00 ± 11.31 | 35.80 ± 19.99 20.00 ± 4.24 |
ALP (U/L) End of dose phase End of recovery phase | 74.87 ± 30.89 56.30 ± 1.84 | 71.90 ± 16.09 57.65 ± 2.05 | 80.18 ± 21.62 53.05 ± 19.59 | 64.44 ± 15.98 47.70 ± 4.10 |
T-BIL(µmol/L) End of dose phase End of recovery phase | 0.64 ± 0.41 0.48 ± 0.04 | 0.86 ± 0.40 0.59 ± 0.12 | 2.25 ± 1.29 0.55 ± 0.03 | 10.59 ± 13.05* 0.86 ± 0.30 |
BUN (mmol/L) End of dose phase End of recovery phase | 4.86 ± 0.78 4.07 ± 0.77 | 4.98 ± 0.64 4.44 ± 1.12 | 5.04 ± 0.66 4.66 ± 0.07 | 6.97 ± 2.42* 6.61 ± 2.96 |
CRE (µmol/L) End of dose phase End of recovery phase | 52.48 ± 5.91 52.30 ± 5.94 | 52.65 ± 5.57 56.20 ± 3.96 | 55.52 ± 6.50 56.00 ± 9.19 | 46.34 ± 9.56 50.90 ± 8.77 |
TP (g/L) End of dose phase End of recovery phase | 62.07 ± 5.69 63.00 ± 5.23 | 60.37 ± 3.81 60.70 ± 0.85 | 60.40 ± 6.14 67.70 ± 0.42 | 58.40 ± 8.32 59.35 ± 10.82 |
ALB (g/L) End of dose phase End of recovery phase | 29.20 ± 3.98 32.75 ± 2.19 | 31.70 ± 1.55 33.60 ± 4.24 | 29.20 ± 2.30 32.60 ± 1.41 | 26.02 ± 4.70 30.70 ± 6.79 |
CHOL (mmol/L) End of dose phase End of recovery phase | 3.88 ± 0.56 4.24 ± 0.31 | 4.28 ± 0.33 4.61 ± 0.25 | 4.28 ± 0.33 5.11 ± 1.04 | 4.33 ± 0.50 4.83 ± 0.49 |
TG (mmol/L) End of dose phase End of recovery phase | 0.38 ± 0.16 0.59 ± 0.08 | 0.47 ± 0.15 0.78 ± 0.01* | 0.48 ± 0.12 0.78 ± 0.05* | 0.70 ± 0.27* 0.77 ± 0.03* |
GLU (mmol/L) End of dose phase End of recovery phase | 4.90 ± 0.21 6.68 ± 0.28 | 5.49 ± 0.37 7.12 ± 0.28 | 5.50 ± 0.33 6.36 ± 0.33 | 5.85 ± 2.17 6.89 ± 0.35 |
CK (U/L) End of dose phase End of recovery phase | 200.83 ± 64.72 290.50 ± 10.61 | 212.00 ± 61.54 238.50 ± 156.27 | 190.50 ± 31.13 140.00 ± 12.73 | 250.60 ± 145.21 153.00 ± 49.50 |
GGT (U/L) End of dose phase End of recovery phase | 2.83 ± 1.60 3.50 ± 0.71 | 2.67 ± 0.82 2.50 ± 0.71 | 2.50 ± 0.84 2.00 ± 0.00 | 3.00 ± 1.73 4.50 ± 3.54 |
K+ (mmol/L) End of dose phase End of recovery phase | 5.02 ± 0.17 4.95 ± 0.21 | 4.80 ± 0.06 4.75 ± 0.21 | 4.63 ± 0.10 4.90 ± 0.14 | 4.24 ± 0.61** 4.95 ± 0.07 |
Na+ (mmol/L) End of dose phase End of recovery phase | 147.67 ± 0.82 148.50 ± 0.71 | 148.00 ± 1.26 147.50 ± 0.71 | 147.50 ± 0.84 149.00 ± 1.41 | 142.60 ± 6.47** 150.50 ± 2.12 |
Cl− (mmol/L) End of dose phase End of recovery phase | 112.00 ± 0.89 113.00 ± 1.41 | 112.17 ± 1.83 113.00 ± 0.00 | 112.00 ± 1.41 115.50 ± 0.71 | 104.20 ± 12.52* 113.50 ± 0.71 |
*P < 0.05, **P < 0.01 vs. Control. Abbreviations: AST, Aspartate aminotransferase; ALT, Alanine aminotransferase; ALP, Alkaline phosphatase; T-BIL, Total bilirubin; BUN, Blood urea nitrogen; CRE, Creatinine; TP, Total protein; ALB, Albumin; CHOL, Cholesterol; TG, Triglyceride; GLU, Glucose; CK, Creatine kinase; GCT, Glutamyl transpeptidase. |