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Table 2 Change in Oral Glucose tolerance test (OGTT) results from baseline

From: Real life evaluation of the multi-organ effects of Lumacaftor/Ivacaftor on F508del homozygous cystic fibrosis patients

Glucose tolerance test results

N

Mean

Std

P-value of change from baseline

Non parametric test

Signed rank test

Baselinea

 Insulin0

6

13.2

10.3

 

 Insulin1

6

81.8

84.5

 

 Insulin2

6

102.3

96.9

 

 Cpeptide0

6

0.3

0.1

 

 Cpeptide1

6

1.1

0.4

 

 Cpeptide2

6

1.6

0.5

 

 Glucose0

8

93.4

6.5

 

 Glucose1

7

151.3

25.3

 

 Glucose2

8

125.8

24.7

 

3 months after treatment

 Insulin0

6

7.1

8.1

0.500

 Insulin1

5

59

80

0.625

 Insulin2

5

47.7

38

0.250

 Cpeptide0

7

0.3

0

0.218

 Cpeptide1

5

1.4

0.4

0.125

 Cpeptide2

5

1.9

1.2

0.875

 Glucose0

7

87.1

15.4

0.328

 Glucose1

7

174.3

52.4

0.218

 Glucose2

7

133.9

34.6

0.468

12 months after treatment

 Insulin0

8

6.1

9.8

0.375

 Insulin1

8

35

58.7

0.125

 Insulin2

8

28

42.8

0.125

 Cpeptide0

8

134.5

378.8

0.812

 Cpeptide1

8

164.7

463.2

0.437

 Cpeptide2

7

38.2

98.7

0.125

 Glucose0

8

98

20.2

0.718

 Glucose1

8

197.9

47.5

0.193

 Glucose2

8

124.4

41.9

0.109

  1. aBaseline units: Insulin (mIU/L), C-peptide (nmol/L), Glucose (mg/dL)